KPTI Deep Analytical Report

Karyopharm Therapeutics Inc. | Category: Equity Micro Cap | Last Updated: 2026-03-24 | Data Range: 2013-11-01 → 2026-03-01 (149 months)
Quick Overview
Timeframe C-C DoR σ
(Historical)
H-L DoR σ
(Historical)
O-C DoR σ
(Historical)
5Y ATRP
(Avg)
Binomial IV
(Period)
Yahoo IV
(Period)
1σ Lower
(68.27%)
1σ Upper 2σ Lower
(95.45%)
2σ Upper
Daily 5.54% 5.24% 4.97% 8.63% 26.42% 25.79% 5.42 9.19 4.16 11.97
Weekly 12.38% 13.28% 12.69% 19.38% 58.15% 56.77% 3.95 12.63 2.21 22.59
Monthly 24.96% 27.14% 26.80% 40.85% 121.05% 118.18% 2.10 23.69 0.63 79.48
Quarterly 33.71% 46.09% 40.84% 67.27% 209.67% 204.69% 0.87 57.46 0.11 467.68
Annual 419.33% 409.38% 0.11 467.68 0.00 30980.47
Option Time Horizon 158.28% 154.52% 1.45 34.37 0.30 167.33
Calculation Notes: Computed at 2026-03-23T16:39 UTC  |  Reference Contract: Call option expiring 2026-05-15 (52 days)  |  Spot Price (S): $7.06  |  Strike (K): $7.50 (first OTM call ≥ spot)  |  Observed Mid-Price: $3.9250 (Bid $1.9500 / Ask $5.9000)  |  Risk-Free Rate (r): 3.73% (1-Month CMT, US Treasury)  |  Dividend Yield (q): 0.00%  |  Binomial IV (Annual): 419.33% (CRR binomial tree, American, n=20 steps)  |  BS IV: 416.28% (European Black-Scholes)  |  Yahoo IV (Annual): 409.38% → period-scaled as σperiod = σannual·√h  |  Price bands: Upper = S·e+σ√h, Lower = S·e−σ√h
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.34. Further, an Excess Kurtosis of 39.88 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -16.59%120.39%0.39%
-16.59% to -12.43%190.61%1.00%
-12.43% to -8.28%822.64%3.63%
-8.28% to -4.12%36911.86%15.50%
-4.12% to 0.03%114436.78%52.28%
0.03% to 4.19%101932.77%85.05%
4.19% to 8.34%32110.32%95.37%
8.34% to 12.50%1003.22%98.59%
12.50% to 16.65%190.61%99.20%
Greater than 16.65%250.80%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -5.51%5.57% 80.26%68.27%
±2σ -11.05%11.11% 96.72%95.45%
±3σ -16.59%16.65% 98.81%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 5.86. Further, an Excess Kurtosis of 71.65 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -8.15%00.00%0.00%
-8.15% to -4.22%00.00%0.00%
-4.22% to -0.29%00.00%0.00%
-0.29% to 3.64%36911.86%11.86%
3.64% to 7.57%157850.72%62.58%
7.57% to 11.50%77224.82%87.40%
11.50% to 15.43%2427.78%95.18%
15.43% to 19.36%742.38%97.56%
19.36% to 23.29%341.09%98.65%
Greater than 23.29%421.35%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 2.33%12.81% 89.78%68.27%
±2σ -2.91%18.05% 96.95%95.45%
±3σ -8.15%23.29% 98.65%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.89. Further, an Excess Kurtosis of 24.60 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -14.62%180.58%0.58%
-14.62% to -10.89%260.84%1.41%
-10.89% to -7.16%1173.76%5.18%
-7.16% to -3.43%37712.12%17.29%
-3.43% to 0.30%101732.69%49.98%
0.30% to 4.03%103633.30%83.29%
4.03% to 7.76%37211.96%95.24%
7.76% to 11.49%1043.34%98.59%
11.49% to 15.22%240.77%99.36%
Greater than 15.22%200.64%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -4.67%5.27% 76.92%68.27%
±2σ -9.64%10.25% 95.72%95.45%
±3σ -14.62%15.22% 98.78%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.06. Further, an Excess Kurtosis of 6.67 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -36.93%40.62%0.62%
-36.93% to -27.65%50.78%1.40%
-27.65% to -18.37%172.64%4.03%
-18.37% to -9.09%8713.49%17.52%
-9.09% to 0.19%22935.50%53.02%
0.19% to 9.47%19930.85%83.88%
9.47% to 18.76%7211.16%95.04%
18.76% to 28.04%162.48%97.52%
28.04% to 37.32%71.09%98.60%
Greater than 37.32%91.40%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -12.18%12.57% 78.60%68.27%
±2σ -24.56%24.94% 95.50%95.45%
±3σ -36.93%37.32% 97.98%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 3.34. Further, an Excess Kurtosis of 16.03 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -20.92%00.00%0.00%
-20.92% to -10.96%00.00%0.00%
-10.96% to -1.00%00.00%0.00%
-1.00% to 8.96%7311.30%11.30%
8.96% to 18.93%35454.80%66.10%
18.93% to 28.89%13821.36%87.46%
28.89% to 38.85%446.81%94.27%
38.85% to 48.81%162.48%96.75%
48.81% to 58.77%81.24%97.99%
Greater than 58.77%132.01%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 5.64%32.21% 90.09%68.27%
±2σ -7.64%45.49% 96.44%95.45%
±3σ -20.92%58.77% 97.99%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.41. Further, an Excess Kurtosis of 8.12 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -36.69%20.31%0.31%
-36.69% to -27.18%71.08%1.39%
-27.18% to -17.66%142.17%3.56%
-17.66% to -8.15%9214.24%17.80%
-8.15% to 1.37%23636.53%54.33%
1.37% to 10.88%19530.19%84.52%
10.88% to 20.39%7110.99%95.51%
20.39% to 29.91%172.63%98.14%
29.91% to 39.42%40.62%98.76%
Greater than 39.42%81.24%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -11.32%14.05% 80.50%68.27%
±2σ -24.00%26.74% 96.13%95.45%
±3σ -36.69%39.42% 98.45%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.77. Further, an Excess Kurtosis of 1.19 proves the distribution possesses Fat Tails (Higher Outlier Risk).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -74.27%00.00%0.00%
-74.27% to -55.55%00.00%0.00%
-55.55% to -36.84%64.05%4.05%
-36.84% to -18.12%2617.57%21.62%
-18.12% to 0.60%5134.46%56.08%
0.60% to 19.32%3825.68%81.76%
19.32% to 38.04%138.78%90.54%
38.04% to 56.76%117.43%97.97%
56.76% to 75.48%00.00%97.97%
Greater than 75.48%32.03%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -24.36%25.56% 71.62%68.27%
±2σ -49.31%50.52% 93.92%95.45%
±3σ -74.27%75.48% 97.97%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.79. Further, an Excess Kurtosis of 3.43 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -35.64%00.00%0.00%
-35.64% to -15.28%00.00%0.00%
-15.28% to 5.08%00.00%0.00%
5.08% to 25.43%2818.79%18.79%
25.43% to 45.79%6946.31%65.10%
45.79% to 66.15%3020.13%85.23%
66.15% to 86.50%85.37%90.60%
86.50% to 106.86%74.70%95.30%
106.86% to 127.22%42.68%97.99%
Greater than 127.22%32.01%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 18.65%72.93% 80.54%68.27%
±2σ -8.50%100.08% 95.30%95.45%
±3σ -35.64%127.22% 97.99%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.16. Further, an Excess Kurtosis of 2.84 proves the distribution possesses Fat Tails (Higher Outlier Risk).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -74.25%00.00%0.00%
-74.25% to -54.15%00.00%0.00%
-54.15% to -34.05%32.01%2.01%
-34.05% to -13.95%3020.13%22.15%
-13.95% to 6.15%4932.89%55.03%
6.15% to 26.25%4026.85%81.88%
26.25% to 46.35%1711.41%93.29%
46.35% to 66.45%74.70%97.99%
66.45% to 86.55%00.00%97.99%
Greater than 86.55%32.01%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -20.65%32.95% 73.15%68.27%
±2σ -47.45%59.75% 95.97%95.45%
±3σ -74.25%86.55% 97.99%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.55. Further, an Excess Kurtosis of -0.31 proves the distribution possesses Normal Tails (Mesokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -103.94%00.00%0.00%
-103.94% to -78.66%00.00%0.00%
-78.66% to -53.38%12.04%2.04%
-53.38% to -28.10%1326.53%28.57%
-28.10% to -2.82%1122.45%51.02%
-2.82% to 22.46%1326.53%77.55%
22.46% to 47.75%714.29%91.84%
47.75% to 73.03%36.12%97.96%
73.03% to 98.31%12.04%100.00%
Greater than 98.31%00.00%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -36.52%30.89% 63.27%68.27%
±2σ -70.23%64.60% 97.96%95.45%
±3σ -103.94%98.31% 100.00%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.05. Further, an Excess Kurtosis of 1.07 proves the distribution possesses Fat Tails (Higher Outlier Risk).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -47.94%00.00%0.00%
-47.94% to -13.38%00.00%0.00%
-13.38% to 21.19%00.00%0.00%
21.19% to 55.76%1224.00%24.00%
55.76% to 90.33%1734.00%58.00%
90.33% to 124.90%1020.00%78.00%
124.90% to 159.47%816.00%94.00%
159.47% to 194.03%12.00%96.00%
194.03% to 228.60%12.00%98.00%
Greater than 228.60%12.00%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 44.24%136.42% 68.00%68.27%
±2σ -1.85%182.51% 96.00%95.45%
±3σ -47.94%228.60% 98.00%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.59. Further, an Excess Kurtosis of -0.40 proves the distribution possesses Normal Tails (Mesokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -107.76%00.00%0.00%
-107.76% to -77.13%00.00%0.00%
-77.13% to -46.50%24.00%4.00%
-46.50% to -15.87%1020.00%24.00%
-15.87% to 14.77%1632.00%56.00%
14.77% to 45.40%918.00%74.00%
45.40% to 76.03%816.00%90.00%
76.03% to 106.66%48.00%98.00%
106.66% to 137.29%12.00%100.00%
Greater than 137.29%00.00%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -26.08%55.61% 68.00%68.27%
±2σ -66.92%96.45% 94.00%95.45%
±3σ -107.76%137.29% 100.00%99.73%