VRTX Deep Analytical Report

Vertex Pharmaceuticals Incorporated | Category: Equity Mega Cap | Last Updated: 2026-02-22 | Data Range: 1991-07-01 → 2026-02-01 (416 months)
Quick Overview
Timeframe C-C DoR σ
(Historical)
H-L DoR σ
(Historical)
O-C DoR σ
(Historical)
5Y ATRP
(Avg)
Binomial IV
(Period)
Yahoo IV
(Period)
1σ Lower
(68.27%)
1σ Upper 2σ Lower
(95.45%)
2σ Upper
Daily 3.47% 2.96% 3.06% 2.35% 2.27% 2.55% 466.17 487.87 455.69 499.10
Weekly 7.64% 7.63% 7.49% 5.32% 5.01% 5.61% 453.61 501.39 431.45 527.14
Monthly 14.99% 17.45% 14.98% 11.22% 10.42% 11.67% 429.69 529.30 387.15 587.45
Quarterly 24.42% 31.30% 22.27% 19.53% 18.06% 20.21% 398.12 571.27 332.35 684.31
Annual 36.11% 40.42% 332.35 684.31 231.62 981.93
Option Time Horizon 13.89% 15.55% 415.06 547.96 361.23 629.61
Calculation Notes: Computed at 2026-02-22T14:18 UTC  |  Reference Contract: Call option expiring 2026-04-17 (54 days)  |  Spot Price (S): $476.90  |  Strike (K): $480.00 (first OTM call ≥ spot)  |  Observed Mid-Price: $26.1000 (Bid $23.8000 / Ask $28.4000)  |  Risk-Free Rate (r): 3.72% (1-Month CMT, US Treasury)  |  Dividend Yield (q): 0.00%  |  Binomial IV (Annual): 36.11% (CRR binomial tree, American, n=20 steps)  |  BS IV: 35.99% (European Black-Scholes)  |  Yahoo IV (Annual): 40.42% → period-scaled as σperiod = σannual·√h  |  Price bands: Upper = S·e+σ√h, Lower = S·e−σ√h
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.54. Further, an Excess Kurtosis of 26.79 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -10.29%420.48%0.48%
-10.29% to -7.69%780.90%1.38%
-7.69% to -5.09%2773.19%4.57%
-5.09% to -2.49%95010.93%15.49%
-2.49% to 0.11%329137.85%53.34%
0.11% to 2.71%277131.87%85.21%
2.71% to 5.31%8459.72%94.93%
5.31% to 7.92%2753.16%98.09%
7.92% to 10.52%860.99%99.08%
Greater than 10.52%800.92%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -3.36%3.58% 79.77%68.27%
±2σ -6.82%7.05% 95.35%95.45%
±3σ -10.29%10.52% 98.60%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.12. Further, an Excess Kurtosis of 7.62 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -4.47%00.00%0.00%
-4.47% to -2.25%00.00%0.00%
-2.25% to -0.03%00.00%0.00%
-0.03% to 2.19%179020.58%20.58%
2.19% to 4.41%362841.72%62.30%
4.41% to 6.63%178420.52%82.82%
6.63% to 8.84%8289.52%92.34%
8.84% to 11.06%3453.97%96.31%
11.06% to 13.28%1631.87%98.18%
Greater than 13.28%1581.82%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 1.45%7.37% 82.36%68.27%
±2σ -1.51%10.32% 95.48%95.45%
±3σ -4.47%13.28% 98.18%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Fairly Symmetrical with a Skewness factor of 0.17. Further, an Excess Kurtosis of 3.54 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -9.12%580.67%0.67%
-9.12% to -6.83%1131.30%1.97%
-6.83% to -4.54%3353.85%5.82%
-4.54% to -2.24%96911.14%16.96%
-2.24% to 0.05%309235.56%52.52%
0.05% to 2.34%264530.42%82.93%
2.34% to 4.64%95610.99%93.93%
4.64% to 6.93%3423.93%97.86%
6.93% to 9.22%1161.33%99.20%
Greater than 9.22%700.80%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -3.01%3.11% 76.35%68.27%
±2σ -6.06%6.17% 94.05%95.45%
±3σ -9.12%9.22% 98.53%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.76. Further, an Excess Kurtosis of 5.91 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -22.38%90.50%0.50%
-22.38% to -16.65%201.11%1.61%
-16.65% to -10.92%553.05%4.66%
-10.92% to -5.19%21011.64%16.30%
-5.19% to 0.54%67137.20%53.49%
0.54% to 6.27%56731.43%84.92%
6.27% to 12.00%1628.98%93.90%
12.00% to 17.73%603.33%97.23%
17.73% to 23.47%281.55%98.78%
Greater than 23.47%221.22%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -7.10%8.18% 80.10%68.27%
±2σ -14.74%15.82% 94.24%95.45%
±3σ -22.38%23.47% 98.28%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.61. Further, an Excess Kurtosis of 11.72 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -12.32%00.00%0.00%
-12.32% to -6.59%00.00%0.00%
-6.59% to -0.87%00.00%0.00%
-0.87% to 4.86%31617.51%17.51%
4.86% to 10.58%83646.32%63.82%
10.58% to 16.31%38721.44%85.26%
16.31% to 22.03%1307.20%92.47%
22.03% to 27.76%673.71%96.18%
27.76% to 33.48%382.11%98.28%
Greater than 33.48%311.72%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 2.95%18.22% 85.43%68.27%
±2σ -4.68%25.85% 95.12%95.45%
±3σ -12.32%33.48% 98.28%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.07. Further, an Excess Kurtosis of 8.64 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -22.40%90.50%0.50%
-22.40% to -16.78%170.94%1.44%
-16.78% to -11.16%673.71%5.15%
-11.16% to -5.54%19210.64%15.79%
-5.54% to 0.07%65036.01%51.80%
0.07% to 5.69%59633.02%84.82%
5.69% to 11.31%1799.92%94.74%
11.31% to 16.93%563.10%97.84%
16.93% to 22.55%241.33%99.17%
Greater than 22.55%150.83%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -7.42%7.57% 79.83%68.27%
±2σ -14.91%15.06% 94.40%95.45%
±3σ -22.40%22.55% 98.67%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.78. Further, an Excess Kurtosis of 3.21 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -42.76%10.24%0.24%
-42.76% to -31.52%30.72%0.96%
-31.52% to -20.28%184.34%5.30%
-20.28% to -9.04%5112.29%17.59%
-9.04% to 2.20%14434.70%52.29%
2.20% to 13.44%12530.12%82.41%
13.44% to 24.68%4510.84%93.25%
24.68% to 35.92%174.10%97.35%
35.92% to 47.16%71.69%99.04%
Greater than 47.16%40.96%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -12.79%17.19% 74.22%68.27%
±2σ -27.78%32.18% 95.90%95.45%
±3σ -42.76%47.16% 98.80%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.47. Further, an Excess Kurtosis of 9.57 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -27.82%00.00%0.00%
-27.82% to -14.73%00.00%0.00%
-14.73% to -1.64%00.00%0.00%
-1.64% to 11.45%6716.11%16.11%
11.45% to 24.54%20048.08%64.18%
24.54% to 37.63%9121.88%86.06%
37.63% to 50.72%235.53%91.59%
50.72% to 63.81%194.57%96.15%
63.81% to 76.90%71.68%97.84%
Greater than 76.90%92.16%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 7.08%41.99% 85.82%68.27%
±2σ -10.37%59.45% 95.67%95.45%
±3σ -27.83%76.90% 97.84%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.33. Further, an Excess Kurtosis of 7.19 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -44.88%00.00%0.00%
-44.88% to -33.65%30.72%0.72%
-33.65% to -22.41%143.37%4.09%
-22.41% to -11.18%5813.94%18.03%
-11.18% to 0.06%15537.26%55.29%
0.06% to 11.29%12129.09%84.38%
11.29% to 22.52%368.65%93.03%
22.52% to 33.76%215.05%98.08%
33.76% to 44.99%40.96%99.04%
Greater than 44.99%40.96%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -14.92%15.03% 75.00%68.27%
±2σ -29.90%30.01% 95.91%95.45%
±3σ -44.88%44.99% 99.04%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.86. Further, an Excess Kurtosis of 1.35 proves the distribution possesses Fat Tails (Higher Outlier Risk).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -67.22%00.00%0.00%
-67.22% to -48.90%00.00%0.00%
-48.90% to -30.58%64.32%4.32%
-30.58% to -12.26%2316.55%20.86%
-12.26% to 6.06%4733.81%54.68%
6.06% to 24.37%3625.90%80.58%
24.37% to 42.69%1712.23%92.81%
42.69% to 61.01%42.88%95.68%
61.01% to 79.33%42.88%98.56%
Greater than 79.33%21.44%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -18.37%30.48% 74.10%68.27%
±2σ -42.79%54.90% 94.96%95.45%
±3σ -67.22%79.33% 98.56%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.71. Further, an Excess Kurtosis of 3.55 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -46.97%00.00%0.00%
-46.97% to -23.50%00.00%0.00%
-23.50% to -0.02%00.00%0.00%
-0.02% to 23.45%3323.57%23.57%
23.45% to 46.92%5740.71%64.29%
46.92% to 70.40%2618.57%82.86%
70.40% to 93.87%139.29%92.14%
93.87% to 117.34%64.29%96.43%
117.34% to 140.82%21.43%97.86%
Greater than 140.82%32.14%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 15.63%78.22% 79.29%68.27%
±2σ -15.67%109.52% 95.00%95.45%
±3σ -46.97%140.82% 97.86%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.68. Further, an Excess Kurtosis of 0.89 proves the distribution possesses Normal Tails (Mesokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -67.37%00.00%0.00%
-67.37% to -50.67%00.00%0.00%
-50.67% to -33.96%85.71%5.71%
-33.96% to -17.26%2215.71%21.43%
-17.26% to -0.56%4733.57%55.00%
-0.56% to 16.14%4129.29%84.29%
16.14% to 32.84%117.86%92.14%
32.84% to 49.54%64.29%96.43%
49.54% to 66.25%42.86%99.29%
Greater than 66.25%10.71%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -22.83%21.71% 73.57%68.27%
±2σ -45.10%43.98% 94.29%95.45%
±3σ -67.37%66.25% 99.29%99.73%