VRTX Deep Analytical Report

Vertex Pharmaceuticals Incorporated | Category: Equity Mega Cap | Last Updated: 2026-03-24 | Data Range: 1991-07-01 → 2026-03-01 (417 months)
Quick Overview
Timeframe C-C DoR σ
(Historical)
H-L DoR σ
(Historical)
O-C DoR σ
(Historical)
5Y ATRP
(Avg)
Binomial IV
(Period)
Yahoo IV
(Period)
1σ Lower
(68.27%)
1σ Upper 2σ Lower
(95.45%)
2σ Upper
Daily 3.47% 2.96% 3.06% 2.36% 2.24% 2.49% 444.69 465.02 434.86 475.54
Weekly 7.63% 7.63% 7.49% 5.35% 4.92% 5.47% 432.91 477.68 412.12 501.77
Monthly 14.98% 17.44% 14.97% 11.30% 10.24% 11.39% 410.47 503.79 370.51 558.13
Quarterly 24.43% 31.28% 22.27% 19.62% 17.74% 19.73% 380.82 543.02 318.91 648.44
Annual 35.48% 39.46% 318.91 648.44 223.65 924.63
Option Time Horizon 13.39% 14.89% 397.74 519.92 347.89 594.43
Calculation Notes: Computed at 2026-03-23T16:33 UTC  |  Reference Contract: Call option expiring 2026-05-15 (52 days)  |  Spot Price (S): $454.74  |  Strike (K): $470.00 (first OTM call ≥ spot)  |  Observed Mid-Price: $19.0500 (Bid $17.1000 / Ask $21.0000)  |  Risk-Free Rate (r): 3.73% (1-Month CMT, US Treasury)  |  Dividend Yield (q): 0.00%  |  Binomial IV (Annual): 35.48% (CRR binomial tree, American, n=20 steps)  |  BS IV: 35.91% (European Black-Scholes)  |  Yahoo IV (Annual): 39.46% → period-scaled as σperiod = σannual·√h  |  Price bands: Upper = S·e+σ√h, Lower = S·e−σ√h
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.54. Further, an Excess Kurtosis of 26.79 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -10.29%420.48%0.48%
-10.29% to -7.69%780.89%1.38%
-7.69% to -5.09%2773.18%4.55%
-5.09% to -2.49%95410.95%15.50%
-2.49% to 0.11%330137.87%53.37%
0.11% to 2.71%277531.84%85.21%
2.71% to 5.31%8479.72%94.93%
5.31% to 7.91%2753.16%98.08%
7.91% to 10.51%871.00%99.08%
Greater than 10.51%800.92%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -3.35%3.58% 79.78%68.27%
±2σ -6.82%7.05% 95.35%95.45%
±3σ -10.29%10.51% 98.60%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.13. Further, an Excess Kurtosis of 7.64 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -4.46%00.00%0.00%
-4.46% to -2.25%00.00%0.00%
-2.25% to -0.03%00.00%0.00%
-0.03% to 2.19%179320.57%20.57%
2.19% to 4.40%364041.76%62.33%
4.40% to 6.62%178620.49%82.82%
6.62% to 8.84%8309.52%92.34%
8.84% to 11.05%3463.97%96.31%
11.05% to 13.27%1631.87%98.18%
Greater than 13.27%1591.82%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 1.45%7.36% 82.37%68.27%
±2σ -1.51%10.31% 95.47%95.45%
±3σ -4.47%13.27% 98.18%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Fairly Symmetrical with a Skewness factor of 0.16. Further, an Excess Kurtosis of 3.54 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -9.12%580.67%0.67%
-9.12% to -6.82%1131.30%1.96%
-6.82% to -4.53%3353.84%5.80%
-4.53% to -2.24%97311.16%16.97%
-2.24% to 0.05%309635.52%52.48%
0.05% to 2.34%265430.45%82.93%
2.34% to 4.64%95911.00%93.93%
4.64% to 6.93%3433.93%97.87%
6.93% to 9.22%1161.33%99.20%
Greater than 9.22%700.80%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -3.00%3.11% 76.37%68.27%
±2σ -6.06%6.16% 94.03%95.45%
±3σ -9.12%9.22% 98.53%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.76. Further, an Excess Kurtosis of 5.93 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -22.36%90.50%0.50%
-22.36% to -16.64%201.11%1.60%
-16.64% to -10.91%553.04%4.65%
-10.91% to -5.19%21011.62%16.26%
-5.19% to 0.54%67337.22%53.48%
0.54% to 6.26%56931.47%84.96%
6.26% to 11.99%1628.96%93.92%
11.99% to 17.71%603.32%97.23%
17.71% to 23.44%281.55%98.78%
Greater than 23.44%221.22%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -7.09%8.17% 80.09%68.27%
±2σ -14.73%15.80% 94.25%95.45%
±3σ -22.36%23.44% 98.29%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.61. Further, an Excess Kurtosis of 11.74 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -12.31%00.00%0.00%
-12.31% to -6.59%00.00%0.00%
-6.59% to -0.87%00.00%0.00%
-0.87% to 4.85%31617.47%17.47%
4.85% to 10.57%84046.43%63.90%
10.57% to 16.30%38721.39%85.30%
16.30% to 22.02%1307.19%92.48%
22.02% to 27.74%673.70%96.19%
27.74% to 33.46%382.10%98.29%
Greater than 33.46%311.71%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 2.95%18.20% 85.46%68.27%
±2σ -4.68%25.83% 95.14%95.45%
±3σ -12.31%33.46% 98.29%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.07. Further, an Excess Kurtosis of 8.66 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -22.38%90.50%0.50%
-22.38% to -16.76%181.00%1.49%
-16.76% to -11.15%673.70%5.20%
-11.15% to -5.54%19110.56%15.75%
-5.54% to 0.08%65236.04%51.80%
0.08% to 5.69%59833.06%84.85%
5.69% to 11.31%1799.89%94.75%
11.31% to 16.92%563.10%97.84%
16.92% to 22.53%241.33%99.17%
Greater than 22.53%150.83%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -7.41%7.56% 79.82%68.27%
±2σ -14.89%15.05% 94.42%95.45%
±3σ -22.38%22.53% 98.67%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.78. Further, an Excess Kurtosis of 3.21 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -42.76%10.24%0.24%
-42.76% to -31.52%30.72%0.96%
-31.52% to -20.29%184.33%5.29%
-20.29% to -9.05%5112.26%17.55%
-9.05% to 2.18%14434.62%52.16%
2.18% to 13.42%12530.05%82.21%
13.42% to 24.65%4611.06%93.27%
24.65% to 35.89%174.09%97.36%
35.89% to 47.12%71.68%99.04%
Greater than 47.12%40.96%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -12.80%17.16% 74.28%68.27%
±2σ -27.78%32.14% 95.91%95.45%
±3σ -42.76%47.12% 98.80%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 2.48. Further, an Excess Kurtosis of 9.59 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -27.82%00.00%0.00%
-27.82% to -14.74%00.00%0.00%
-14.74% to -1.65%00.00%0.00%
-1.65% to 11.43%6716.07%16.07%
11.43% to 24.51%20047.96%64.03%
24.51% to 37.59%9222.06%86.09%
37.59% to 50.67%235.52%91.61%
50.67% to 63.75%194.56%96.16%
63.75% to 76.83%71.68%97.84%
Greater than 76.83%92.16%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 7.07%41.95% 86.09%68.27%
±2σ -10.38%59.39% 95.68%95.45%
±3σ -27.82%76.84% 97.84%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.33. Further, an Excess Kurtosis of 7.19 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -44.84%00.00%0.00%
-44.84% to -33.62%30.72%0.72%
-33.62% to -22.39%143.36%4.08%
-22.39% to -11.16%5813.91%17.99%
-11.16% to 0.07%15537.17%55.16%
0.07% to 11.30%12229.26%84.41%
11.30% to 22.52%368.63%93.05%
22.52% to 33.75%215.04%98.08%
33.75% to 44.98%40.96%99.04%
Greater than 44.98%40.96%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -14.90%15.04% 75.06%68.27%
±2σ -29.87%30.01% 95.92%95.45%
±3σ -44.84%44.98% 99.04%99.73%
Close-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.86. Further, an Excess Kurtosis of 1.35 proves the distribution possesses Fat Tails (Higher Outlier Risk).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -67.28%00.00%0.00%
-67.28% to -48.95%00.00%0.00%
-48.95% to -30.63%64.32%4.32%
-30.63% to -12.30%2316.55%20.86%
-12.30% to 6.02%4733.81%54.68%
6.02% to 24.35%3625.90%80.58%
24.35% to 42.67%1712.23%92.81%
42.67% to 61.00%42.88%95.68%
61.00% to 79.32%42.88%98.56%
Greater than 79.32%21.44%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -18.41%30.46% 74.10%68.27%
±2σ -42.85%54.89% 94.96%95.45%
±3σ -67.28%79.32% 98.56%99.73%
High-to-Low Returns
Gram-Charlier Analysis: Data reveals Highly Right Skewed (Extreme Positive Tail Risk) with a Skewness factor of 1.71. Further, an Excess Kurtosis of 3.56 proves the distribution possesses Extreme Fat Tails (Frequent Outliers, Leptokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -46.91%00.00%0.00%
-46.91% to -23.45%00.00%0.00%
-23.45% to 0.02%00.00%0.00%
0.02% to 23.48%3323.57%23.57%
23.48% to 46.94%5740.71%64.29%
46.94% to 70.40%2618.57%82.86%
70.40% to 93.86%139.29%92.14%
93.86% to 117.32%64.29%96.43%
117.32% to 140.79%21.43%97.86%
Greater than 140.79%32.14%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ 15.66%78.22% 79.29%68.27%
±2σ -15.62%109.50% 95.00%95.45%
±3σ -46.91%140.79% 97.86%99.73%
Open-to-Close Returns
Gram-Charlier Analysis: Data reveals Right Skewed (Positive Asymmetry) with a Skewness factor of 0.67. Further, an Excess Kurtosis of 0.89 proves the distribution possesses Normal Tails (Mesokurtic).
Bin Distribution Over Raw Range
Bin / RangeFrequencyProbCum. Prob
Less than -67.34%00.00%0.00%
-67.34% to -50.64%00.00%0.00%
-50.64% to -33.93%85.71%5.71%
-33.93% to -17.23%2215.71%21.43%
-17.23% to -0.53%4632.86%54.29%
-0.53% to 16.18%4230.00%84.29%
16.18% to 32.88%117.86%92.14%
32.88% to 49.58%64.29%96.43%
49.58% to 66.29%42.86%99.29%
Greater than 66.29%10.71%100.00%
Standard Deviation Interval Analysis
SDLower BndUpper Bnd Actual %Normal %
±1σ -22.80%21.75% 73.57%68.27%
±2σ -45.07%44.02% 94.29%95.45%
±3σ -67.34%66.29% 99.29%99.73%